Original English content reproduced with permission. Source claims have not been independently validated by Peps MN. Peptide DB ↗
NA-Selank Amidate (N-Acetyl Selank Amidate)
N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic
200-500mcg per administration
1-2x daily for 14-20 days
2-3 weeks (14-20 days)
Refrigerate at 2-8°C
Original Peptide DB content reproduced with permission. Source claims have not been independently validated by Peps MN. Source ↗
NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics. The N-acetyl group improves blood-brain barrier penetration and creates more stable metabolites, while the C-terminal amidation further enhances metabolic stability and receptor binding. Unlike benzodiazepines, it provides anxiety relief without sedation, dependency, or cognitive impairment.
NA-Selank Amidate modulates multiple neurotransmitter systems including GABA, dopamine, and serotonin, while regulating brain-derived neurotrophic factor (BDNF). It allosterically modulates GABAA receptors without causing the sedation or dependency of benzodiazepines. The peptide activates serotonin metabolism in the hypothalamus and brainstem, and increases BDNF levels to promote neuronal growth and differentiation.
Molecular Data
?TKPRPGP?Ac
Position 1
Threonine
Position 2
Lysine
Position 3
Proline
Position 4
Arginine
Position 5
Proline
Position 6
Glycine
Position 7
Proline
Position 8
NH2
Position 9
Accumulation Curve
Example inputs are illustrative, not a dosing protocol.
Research Indications
Standard Selank approved in Russia for GAD; NA-Selank Amidate offers enhanced delivery.
Modulates stress response through GABA and serotonin systems without sedation.
Improves mood through serotonin metabolism activation.
Increases memory trace stability for up to 30 days in animal studies.
BDNF elevation supports learning and neuroplasticity.
BDNF increase reduces effects of neurological injury.
Based on tuftsin structure, retains immunomodulatory properties.
Dosing Protocols
Intranasal spray is the preferred delivery method, providing direct access to the brain while bypassing first-pass metabolism. The N-acetyl and amide modifications enhance absorption and stability.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Anxiety relief | 250-500 mcg | 1-2x daily | Intranasal |
| Cognitive enhancement | 200-400 mcg | 1-2x daily | Intranasal |
| Standard protocol | 300 mcg | 1-2x daily for 14 days | Intranasal |
Subcutaneous injection is an alternative to intranasal delivery, though nasal spray is generally preferred for this peptide.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Alternative delivery | 250-500 mcg | 1-2x daily | SubQ |
Reconstitution Instructions
- Bacteriostatic water (BAC)
- Insulin syringes
- Alcohol swabs
- Peptide vial
- Sterile work surface
- 1 Clean work area and hands thoroughly
- 2 Calculate required BAC water volume
- 3 Draw BAC water into syringe
- 4 Inject slowly down vial side
- 5 Gently swirl until dissolved (never shake)
- 6 Store in refrigerator
Interactions
What to Expect
Side Effects & Safety
Common Side Effects
- Generally well-tolerated
- Mild nasal irritation (intranasal)
- Fatigue (rare)
Stop Signs - Discontinue if:
- Allergic reactions
- Paradoxical anxiety increase
- Unusual mood changes
Contraindications
- Pregnancy or breastfeeding
- Known hypersensitivity to Selank or tuftsin
- Severe psychiatric conditions (consult professional)
Quality Checklist
Good Signs
- White to off-white lyophilized powder
- Clear solution after reconstitution
- Intact vacuum seal
Warning Signs
- Slight clumping that dissolves easily
Bad Signs
- Discolored powder
- Cloudy or particulate solution
- Unusual odor
Frequently Asked Questions
How is NA-Selank Amidate different from standard Selank?
NA-Selank Amidate has two key modifications: N-terminal acetylation and C-terminal amidation. These changes enhance blood-brain barrier penetration, create more stable metabolites, and extend the half-life compared to standard Selank. The result is superior anxiolytic and cognitive effects with potentially longer duration of action.
Can I use NA-Selank Amidate without taking breaks between cycles?
No. The file recommends limiting cycles to 2-3 weeks with breaks between them to prevent potential GABAergic desensitization. Continuous use without breaks may reduce effectiveness over time, similar to tolerance that develops with benzodiazepines, though NA-Selank Amidate has no reported dependency.
Does intranasal NA-Selank Amidate work faster than injection?
Yes. The intranasal route provides direct access to the brain and has faster onset (15-30 minutes) compared to subcutaneous injection. However, both routes are effective—the choice depends on convenience and bioavailability preferences.
Will NA-Selank Amidate interfere with my anxiety medication?
That depends on your medication. NA-Selank Amidate works through GABA and serotonin systems. If you're on benzodiazepines or SSRIs, consult your healthcare provider before combining, as the effects may be additive. The peptide is designed to work without causing the sedation or dependence of benzodiazepines, making it potentially safer when used under guidance.
References
- Selank Administration Affects Expression of Genes in GABAergic NeurotransmissionFrontiers in Pharmacology (2016)
Selank modulates GABAA receptor activity, contributing to anxiolytic effects without benzodiazepine-like side effects.
- Selank Clinical Trial in Anxiety DisordersZhurnal Nevrologii i Psikhiatrii (2008)
14 days of intranasal Selank produced pronounced anxiolytic and mild nootropic effects; benefits persisted 1 week post-treatment.
- Selank and Serotonin MetabolismBulletin of Experimental Biology and Medicine (2006)
Single Selank injection activated serotonin metabolism and increased memory trace stability for up to 30 days.
- Selank and BDNF ExpressionRegulatory Peptides (2009)
Selank administration increases BDNF levels, supporting neuronal growth and memory enhancement.
Related Peptides
Disclaimer
This information is for educational and research purposes only. Consult a healthcare professional before use.
For education and research information only. Not individualized medical advice.